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Dr Gwee Kok Ann

MBBS (Singapore)
M Med (Internal Medicine)
PhD (Sheffield)
FAMS (Gastroenterology)
FRCP (London & Glasgow)

Dr. Gwee Kok Ann

Gastroenterologist and Physician
The Gastroenterology Group

Adjunct Associate Professor of Medicine
National University of Singapore

Gwee Kok Ann, MBBS, FAMS (Gastroenterology), FRCP, PhD, practices at Gleneagles Hospital. He obtained his medical degree from National University of Singapore in 1985, completed his gastroenterology training at National University Hospital, Singapore, undertook further training in UK and Canada, and was awarded a PhD from University of Sheffield for his thesis on Post-infectious IBS.


He is a leading authority on irritable bowel syndrome (IBS) and constipation, being the lead author of position papers on IBS, use of probiotics for digestive disorders, dyspepsia and constipation. He was a member of the Rome Committee that publishes international guidelines for research and management of functional GI disorders, past president of the IBS Support Group (a patient self-help group), the ANMA (an Asian expert panel organisation dedicated to the science and practice of neurogastroenterology and motility), and recipient of the Rome Foundation Research Award 2014. 


Dr Gwee is also Adjunct Associate Professor of Medicine at the National University of Singapore. Professor Gwee has international publications on the role of probiotics in clinical management, post-infectious IBS, the roles of melatonin, sleep disturbance and gluten sensitivity in IBS, endoscopic evaluation of gastro-esophageal reflux disease, and the effect of Helicobacter pylori treatment in dyspepsia. In addition to the management of stomach, liver and bowel disorders, Dr Gwee provides expertise in the management of dyspepsia, indigestion, gas related complaints, bowel habit training and dietary management of food intolerance, refractory GERD and H pylori infection, and small intestinal bacterial overgrowth. His specific hepatology interests are the management of fatty liver and hepatitis E.


  1. Gwee KA. Bowel disturbances following acute gastroenteritis: a psychobiophysiological model for the irritable bowel syndrome. PhD thesis, University of Sheffield, 1997.

  2. Read NW, Celik AF, Gwee KA, Tomlin J. The Colon. In: Current Gastroenterology 1994;14:85-113. Editor: Gary Gitnick. Mosby Year Book, LA.

  3. Survival Guide to Acute Medicine, 1998, section “Constipation”, eds Lee KH, Wong J, Tan CC, Singapore University Press, Singapore.

  4. “Doctor, I’m Worried” 2000, section “Toilet trouble”, eds Kua EH, Goh LG, Times Books International, Singapore.

  5. Gwee KA, McKendrick MW. Management of persistent post-infectious diarrhea. In: Infectious Diseases. 2nd edition. Editors: Armstrong & Cohen. Mosby, London 2003.

  6. Gwee KA. Constipation. In: Management of Chronic Gastroenterological Problems: A Malaysia & Malaysia Singapore Perspective. 4th edition. Editors: Guan, Ho & Ng. Ezyhealth Singapore 2006.

  7. Gwee KA, Read NW. Rolling review: disorders of gastrointestinal motility - therapeutic potentials and limitations. Aliment Pharmacol Ther 1994;8:105-118.

  8. Read NW, Gwee KA. The importance of 5-HT receptors in the gut.  Pharmacology and Therapeutics 1994;62:159-174.

  9. Kang JY,  Gwee KA,  Yap I.  The colonic air insufflation test indicates a colonic cause of abdominal pain. An aid in the management of irritable bowel syndrome. J Clin Gastroenterol 1994;18:19-22.

  10. Kang JY, Yap I, Gwee KA. The pattern of functional and organic disorders in an Asian gastroenterological clinic. J Gastroenterol Hepatol 1994;9:124-127.

  11. Fock KM, Kang JY, Ng HS, Ng TM, Gwee KA, Lim CC. Roxatidine versus ranitidine in the treatment of duodenal ulcers: a randomised double-blind controlled multicentre study in Singapore. J Gastroenterol Hepatol 1995;10:379-382.

  12. Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ, Read NW. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 1996;347:150-153.

  13. Gwee KA. Irritable bowel syndrome: psychology, biology, and warfare between false dichotomies. Lancet 1996;347:1267.

  14. 14.Yeoh KG, Kang JY, Tay HH, Gwee KA, Tan CC, Wee A, Teh M, Choo HF, Chintana-Wilde W. E. Effect of cisapride on functional dyspepsia in patients with and without histological gastritis: a double-blind placebo-controlled trial. J Gastroenterol Hepatol 1997;12:13-18.

  15. Lee HS, Gwee KA, Teng LY, Kang JY, Yeoh KG, Wee A, Chua BC. Validation of 13C-urea breath test for Helicobacter pylori using a simple gas chromatograph-mass selective detector. Eur J Gastroenterol Hepatol 1998;10:569-72.

  16. Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, SJ Walters, JE Underwood, Read NW. The role of psychological and biological factors in postinfective gut dysfunction. Gut 1999;44:400-6.

  17. Gwee KA. Postinfectious irritable bowel syndrome. Current Treatment Options in Gastroenterology 2001;4:287-291.

  18. Gwee KA, Collins SM, Read NW, Rajnakova A, Deng YK, Graham JC, McKendrick MW, Moochhala SM. Increased rectal mucosal expression of interleukin 1 beta in recently acquired post infectious irritable bowel syndrome. Gut 2003;52:523-6.

  19. Kellow JE, Lee OY, Chang FY, Thongsawat S, Mazlam MZ, Yuen H, Gwee KA, Bak YT, Jones J, Wagner A. An Asia-Pacific, double-blind, placebo-controlled, randomised study to evaluate the efficacy, safety and tolerability of tegaserod in patients with irritable bowel syndrome. Gut 2003;52:671-6.

  20. Gwee KA, Wee S, Wong ML, Png DJ. The Prevalence, Symptom Characteristics and Impact of Irritable Bowel Syndrome in an Asian Urban Community. Am J Gastroenterology 2004;99:924-31.

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